Nature Communications (Nov 2022)
Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51
- Anne Margriet Heijink,
- Colin Stok,
- David Porubsky,
- Eleni Maria Manolika,
- Jurrian K. de Kanter,
- Yannick P. Kok,
- Marieke Everts,
- H. Rudolf de Boer,
- Anastasia Audrey,
- Femke J. Bakker,
- Elles Wierenga,
- Marcel Tijsterman,
- Victor Guryev,
- Diana C. J. Spierings,
- Puck Knipscheer,
- Ruben van Boxtel,
- Arnab Ray Chaudhuri,
- Peter M. Lansdorp,
- Marcel A. T. M. van Vugt
Affiliations
- Anne Margriet Heijink
- Department of Medical Oncology, University Medical Center Groningen, University of Groningen, the Netherlands
- Colin Stok
- Department of Medical Oncology, University Medical Center Groningen, University of Groningen, the Netherlands
- David Porubsky
- European Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen
- Eleni Maria Manolika
- Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center
- Jurrian K. de Kanter
- Princess Máxima Center for Pediatric Oncology
- Yannick P. Kok
- Department of Medical Oncology, University Medical Center Groningen, University of Groningen, the Netherlands
- Marieke Everts
- Department of Medical Oncology, University Medical Center Groningen, University of Groningen, the Netherlands
- H. Rudolf de Boer
- Department of Medical Oncology, University Medical Center Groningen, University of Groningen, the Netherlands
- Anastasia Audrey
- Department of Medical Oncology, University Medical Center Groningen, University of Groningen, the Netherlands
- Femke J. Bakker
- Department of Medical Oncology, University Medical Center Groningen, University of Groningen, the Netherlands
- Elles Wierenga
- Department of Medical Oncology, University Medical Center Groningen, University of Groningen, the Netherlands
- Marcel Tijsterman
- Department of Human Genetics, Leiden University Medical Center
- Victor Guryev
- European Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen
- Diana C. J. Spierings
- European Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen
- Puck Knipscheer
- Oncode Institute
- Ruben van Boxtel
- Princess Máxima Center for Pediatric Oncology
- Arnab Ray Chaudhuri
- Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center
- Peter M. Lansdorp
- European Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen
- Marcel A. T. M. van Vugt
- Department of Medical Oncology, University Medical Center Groningen, University of Groningen, the Netherlands
- DOI
- https://doi.org/10.1038/s41467-022-34519-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Sister chromatid exchanges (SCEs) are considered to be products of homologous recombination repair. The authors show that SCEs can arise independently of homologous recombination due to processing of replication intermediates during mitosis.
