Journal of the Serbian Chemical Society (Aug 2000)

Valine-mediated borane reduction of ketones

  • J. N. MILOVANOVIC,
  • B. M. MOJSILOVIC,
  • M. D. JOKSOVIC,
  • S. K. KONSTANTINOVIC,
  • A. V. TEODOROVIC

Journal volume & issue
Vol. 65, no. 8
pp. 549 – 553

Abstract

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Acetophenone, 3,3-dimethyl-2-butanone, 3-methyl-2-butanone, and 2-pentanone were reduced with (S)-valine-mediated borane in very good yields (86-91 %) giving predominantly alcohols of the (R)-configuration (80, 64, 55 and 36 % ee, respectively).

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