Nature Communications (Apr 2018)
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia
- Jayaram Vijayakrishnan,
- James Studd,
- Peter Broderick,
- Ben Kinnersley,
- Amy Holroyd,
- Philip J. Law,
- Rajiv Kumar,
- James M. Allan,
- Christine J. Harrison,
- Anthony V. Moorman,
- Ajay Vora,
- Eve Roman,
- Sivaramakrishna Rachakonda,
- Sally E. Kinsey,
- Eamonn Sheridan,
- Pamela D. Thompson,
- Julie A. Irving,
- Rolf Koehler,
- Per Hoffmann,
- Markus M. Nöthen,
- Stefanie Heilmann-Heimbach,
- Karl-Heinz Jöckel,
- Douglas F. Easton,
- Paul D. P. Pharaoh,
- Alison M. Dunning,
- Julian Peto,
- Frederico Canzian,
- Anthony Swerdlow,
- Rosalind A. Eeles,
- ZSofia Kote-Jarai,
- Kenneth Muir,
- Nora Pashayan,
- The PRACTICAL Consortium,
- Mel Greaves,
- Martin Zimmerman,
- Claus R. Bartram,
- Martin Schrappe,
- Martin Stanulla,
- Kari Hemminki,
- Richard S. Houlston
Affiliations
- Jayaram Vijayakrishnan
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- James Studd
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Peter Broderick
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Ben Kinnersley
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Amy Holroyd
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Philip J. Law
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Rajiv Kumar
- Division of Molecular Genetic Epidemiology, German Cancer Research Centre
- James M. Allan
- Northern Institute for Cancer Research, Newcastle University
- Christine J. Harrison
- Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University
- Anthony V. Moorman
- Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University
- Ajay Vora
- Department of Haematology, Great Ormond Street Hospital
- Eve Roman
- Department of Health Sciences, University of York
- Sivaramakrishna Rachakonda
- Division of Molecular Genetic Epidemiology, German Cancer Research Centre
- Sally E. Kinsey
- Department of Paediatric and Adolescent Haematology and Oncology, Leeds General Infirmary
- Eamonn Sheridan
- Medical Genetics Research Group, Leeds Institute of Molecular Medicine, University of Leeds
- Pamela D. Thompson
- Paediatric and Familial Cancer Research Group, Institute of Cancer Sciences, St. Mary’s Hospital
- Julie A. Irving
- Northern Institute for Cancer Research, Newcastle University
- Rolf Koehler
- Department of Human Genetics, Institute of Human Genetics, University of Heidelberg
- Per Hoffmann
- Department of Genomics, Institute of Human Genetics, Life & Brain Centre, University of Bonn
- Markus M. Nöthen
- Department of Genomics, Institute of Human Genetics, Life & Brain Centre, University of Bonn
- Stefanie Heilmann-Heimbach
- Department of Genomics, Institute of Human Genetics, Life & Brain Centre, University of Bonn
- Karl-Heinz Jöckel
- Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg–Essen
- Douglas F. Easton
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Paul D. P. Pharaoh
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Alison M. Dunning
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Laboratory
- Julian Peto
- Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine
- Frederico Canzian
- Genomic Epidemiology Group, German Cancer Research Center (DKFZ)
- Anthony Swerdlow
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Rosalind A. Eeles
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- ZSofia Kote-Jarai
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Kenneth Muir
- Institute of Population Health, University of Manchester
- Nora Pashayan
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- The PRACTICAL Consortium
- Mel Greaves
- Centre for Evolution and Cancer, Institute of Cancer Research
- Martin Zimmerman
- Department of Paediatric Haematology and Oncology, Hannover Medical School
- Claus R. Bartram
- Department of Human Genetics, Institute of Human Genetics, University of Heidelberg
- Martin Schrappe
- General Paediatrics, University Hospital Schleswig-Holstein
- Martin Stanulla
- Department of Paediatric Haematology and Oncology, Hannover Medical School
- Kari Hemminki
- Division of Molecular Genetic Epidemiology, German Cancer Research Centre
- Richard S. Houlston
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- DOI
- https://doi.org/10.1038/s41467-018-03178-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
While GWAS have uncovered susceptibility loci for B-cell precursor acute lymphoblastic leukemia (BCP-ALL), much of the heritable risk remains undiscovered. Here, the authors perform a meta-analysis of two existing BCP-ALL GWAS together with an unpublished GWAS to identify risk loci at 8q24.21 and 2q22.3.
