Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin

Wen-Long Sun; Sha Hua; Xin-Yu Li; Liang Shen; Hao Wu; Hong-Fang Ji

doi:10.1038/s41467-023-36079-x

Nature Communications (Jan 2023)

Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin

Wen-Long Sun,
Sha Hua,
Xin-Yu Li,
Liang Shen,
Hao Wu,
Hong-Fang Ji

Affiliations

Wen-Long Sun: Institute of Biomedical Research, School of Life Sciences and Medicine, Shandong University of Technology
Sha Hua: Department of Cardiology, Ruijin Hospital/Luwan Branch, Shanghai Jiao Tong University School of Medicine
Xin-Yu Li: Institute of Biomedical Research, School of Life Sciences and Medicine, Shandong University of Technology
Liang Shen: Institute of Biomedical Research, School of Life Sciences and Medicine, Shandong University of Technology
Hao Wu: State Key Laboratory of Genetic Engineering, Human Phenome Institute, and Department of Bariatric and Metabolic Surgery, Huashan Hospital, Fudan University
Hong-Fang Ji: Institute of Biomedical Research, School of Life Sciences and Medicine, Shandong University of Technology

DOI: https://doi.org/10.1038/s41467-023-36079-x
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 13

Abstract

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Silymarin has been used for improving hepatic damage and lipid disorders, but its action mechanism remains to be clarified. Here, the authors reveal a mechanism of action underpinning the lipid-lowering effect of silymarin via the gut microbiota and its vitamin B12 producing capabilities.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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