Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

Kristine Williams; Lars R. Ingerslev; Jette Bork-Jensen; Martin Wohlwend; Ann Normann Hansen; Lewin Small; Rasmus Ribel-Madsen; Arne Astrup; Oluf Pedersen; Johan Auwerx; Christopher T. Workman; Niels Grarup; Torben Hansen; Romain Barrès

doi:10.1038/s41467-020-16537-6

Nature Communications (Jun 2020)

Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

Kristine Williams,
Lars R. Ingerslev,
Jette Bork-Jensen,
Martin Wohlwend,
Ann Normann Hansen,
Lewin Small,
Rasmus Ribel-Madsen,
Arne Astrup,
Oluf Pedersen,
Johan Auwerx,
Christopher T. Workman,
Niels Grarup,
Torben Hansen,
Romain Barrès

Affiliations

Kristine Williams: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Lars R. Ingerslev: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Jette Bork-Jensen: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Martin Wohlwend: Laboratory of Integrative and Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne
Ann Normann Hansen: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Lewin Small: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Rasmus Ribel-Madsen: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Arne Astrup: Department of Nutrition, Exercise and Sports Science, Faculty of Science, University of Copenhagen
Oluf Pedersen: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Johan Auwerx: Laboratory of Integrative and Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne
Christopher T. Workman: Department of Biotechnology and Biomedicine, Technical University of Denmark
Niels Grarup: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Torben Hansen: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Romain Barrès: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen

DOI: https://doi.org/10.1038/s41467-020-16537-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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Obesity and type 2 diabetes (T2D) are metabolic disorders characterized by insulin resistance in skeletal muscle. Here, the authors map skeletal muscle enhancer elements dynamically regulated after exposure to free fatty acid palmitate or inflammatory cytokine TNFα and identify target genes involved in metabolic dysfunction in skeletal muscle.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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