Seropositivity of Cytomegalovirus, Rubella and Toxoplasma Gondii in Pregnant Women and IgG Avidity Tests

Abstract

Purpose: Cytomegalovirus (CMV), Rubella, and Toxoplasma gondii (T.gondii) infections cause congenital malformations in the fetus when they occur in pregnant women, especially in the first trimester. This study aimed to determine the seropositivity of CMV, Rubella, and T.gondii in pregnant women. Materials and Methods: CMV, Rubella, and T. gondii seropositivity rates of pregnant women who applied to the Aksaray Training and Research Hospital Microbiology Laboratory between July 2019 and June 2021 were evaluated. In addition, the avidity test results studied during this period were included in the study. Results: A total of 3218 pregnant women were included in the study. CMV, Rubella, and T.gondii IgM seropositivity rates were 1.9%, 0.8%, and 1.4%, respectively, and these rates for IgG were 97.3%, 83.9%, and 21%, respectively. All the samples were found to have high avidity in CMV and Rubella. In the T.gondii group, 93.7% of women had high, and 6.7% had low avidity. Conclusion: CMV, Rubella, and T.gondii seropositivity were determined for the first time in Aksaray province in this study. These rates we found are similar to other studies in our country. No difference was found in CMV IgM and IgG according to age groups, while a decrease was found in Rubella with age. In T.gondii, on the other hand, it was observed that there was an increase in IgG with age, while the rate did not change in IgM.

Keywords

• cytomegalovirus
• rubella
• toxoplasma gondii
• avidity
• pergnancy