Nature Communications (Mar 2021)
Circadian control of hepatitis B virus replication
- Xiaodong Zhuang,
- Donall Forde,
- Senko Tsukuda,
- Valentina D’Arienzo,
- Laurent Mailly,
- James M. Harris,
- Peter A. C. Wing,
- Helene Borrmann,
- Mirjam Schilling,
- Andrea Magri,
- Claudia Orbegozo Rubio,
- Robert J. Maidstone,
- Mudassar Iqbal,
- Miguel Garzon,
- Rosalba Minisini,
- Mario Pirisi,
- Sam Butterworth,
- Peter Balfe,
- David W. Ray,
- Koichi Watashi,
- Thomas F. Baumert,
- Jane A. McKeating
Affiliations
- Xiaodong Zhuang
- Nuffield Department of Medicine, University of Oxford
- Donall Forde
- Nuffield Department of Medicine, University of Oxford
- Senko Tsukuda
- Nuffield Department of Medicine, University of Oxford
- Valentina D’Arienzo
- Nuffield Department of Medicine, University of Oxford
- Laurent Mailly
- University of Strasbourg and Inserm, UMR-S1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- James M. Harris
- Nuffield Department of Medicine, University of Oxford
- Peter A. C. Wing
- Nuffield Department of Medicine, University of Oxford
- Helene Borrmann
- Nuffield Department of Medicine, University of Oxford
- Mirjam Schilling
- Nuffield Department of Medicine, University of Oxford
- Andrea Magri
- Nuffield Department of Medicine, University of Oxford
- Claudia Orbegozo Rubio
- Nuffield Department of Medicine, University of Oxford
- Robert J. Maidstone
- NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital
- Mudassar Iqbal
- Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Miguel Garzon
- Division of Pharmacy and Optometry, School of Health Sciences and Manchester Academic Health Sciences Centre, University of Manchester
- Rosalba Minisini
- Department of Translational Medicine, Università del Piemonte Orientale
- Mario Pirisi
- Department of Translational Medicine, Università del Piemonte Orientale
- Sam Butterworth
- Division of Pharmacy and Optometry, School of Health Sciences and Manchester Academic Health Sciences Centre, University of Manchester
- Peter Balfe
- Nuffield Department of Medicine, University of Oxford
- David W. Ray
- NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital
- Koichi Watashi
- Department of Virology II, National Institute of Infectious Diseases
- Thomas F. Baumert
- University of Strasbourg and Inserm, UMR-S1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Jane A. McKeating
- Nuffield Department of Medicine, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-021-21821-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
The circadian factors BMAL1/CLOCK and REV-ERB are master regulators of the human liver transcriptome but their role in hepatitis B virus infection is largely unknown. Here, Zhuang et al. show that REV-ERB regulates hepatitis B virus entry and BMAL1 directly binds HBV DNA and activates viral genome transcription.
