Nature Communications (Feb 2021)

Quantifying information accumulation encoded in the dynamics of biochemical signaling

  • Ying Tang,
  • Adewunmi Adelaja,
  • Felix X.-F. Ye,
  • Eric Deeds,
  • Roy Wollman,
  • Alexander Hoffmann

DOI
https://doi.org/10.1038/s41467-021-21562-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

Read online

Understanding how cells discriminate between stimuli is an ongoing challenge. Here, the authors propose a mathematical framework for inferring the mutual information encoded in temporal signaling dynamics and use it to study how information is transmitted over time in response to different stimuli in NFκB, MAPK and p53 signaling pathways.