SENP3-Mediated PPARγ2 DeSUMOylation in BM-MSCs Potentiates Glucocorticoid-Induced Osteoporosis by Promoting Adipogenesis and Weakening Osteogenesis

Yongxing Zhang; Yongxing Zhang; Yongxing Zhang; Yang Chen; Hangxiang Sun; Hangxiang Sun; Wenkan Zhang; Wenkan Zhang; Lingling Zhang; Lingling Zhang; Hengyuan Li; Hengyuan Li; Xin Huang; Xin Huang; Jie Yang; Zhaoming Ye; Zhaoming Ye

doi:10.3389/fcell.2021.693079

Frontiers in Cell and Developmental Biology (Jun 2021)

SENP3-Mediated PPARγ2 DeSUMOylation in BM-MSCs Potentiates Glucocorticoid-Induced Osteoporosis by Promoting Adipogenesis and Weakening Osteogenesis

Yongxing Zhang,
Yongxing Zhang,
Yongxing Zhang,
Yang Chen,
Hangxiang Sun,
Hangxiang Sun,
Wenkan Zhang,
Wenkan Zhang,
Lingling Zhang,
Lingling Zhang,
Hengyuan Li,
Hengyuan Li,
Xin Huang,
Xin Huang,
Jie Yang,
Zhaoming Ye,
Zhaoming Ye

Affiliations

Yongxing Zhang: Musculoskeletal Tumor Center, Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Yongxing Zhang: Institute of Orthopedic Research, Zhejiang University, Hangzhou, China
Yongxing Zhang: Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Yang Chen: Department of Ultrasound, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Hangxiang Sun: Musculoskeletal Tumor Center, Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Hangxiang Sun: Institute of Orthopedic Research, Zhejiang University, Hangzhou, China
Wenkan Zhang: Musculoskeletal Tumor Center, Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Wenkan Zhang: Institute of Orthopedic Research, Zhejiang University, Hangzhou, China
Lingling Zhang: Musculoskeletal Tumor Center, Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Lingling Zhang: Institute of Orthopedic Research, Zhejiang University, Hangzhou, China
Hengyuan Li: Musculoskeletal Tumor Center, Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Hengyuan Li: Institute of Orthopedic Research, Zhejiang University, Hangzhou, China
Xin Huang: Musculoskeletal Tumor Center, Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Xin Huang: Institute of Orthopedic Research, Zhejiang University, Hangzhou, China
Jie Yang: Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Zhaoming Ye: Musculoskeletal Tumor Center, Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Zhaoming Ye: Institute of Orthopedic Research, Zhejiang University, Hangzhou, China

DOI: https://doi.org/10.3389/fcell.2021.693079
Journal volume & issue: Vol. 9

Abstract

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Glucocorticoid-induced osteoporosis (GIOP) is the most common secondary osteoporosis and reduced bone formation was the main pathological change in GIOP. Our previous studies have shown that there was an imbalance between adipogenic and osteogenic differentiation in GIOP BM-MSCs and peroxisome proliferator-activated receptor γ2 (PPARγ2) played a vital role in this disorders. Here, we reported that there was an increase in ROS level and SENP3 expression in Dex-induced osteoporotic BM-MSCs, and enhanced adipogenesis and weakened osteogenesis in osteoporotic BM-MSCs might be caused by upregulated SENP3. Then we found that SENP3 de-SUMOylated PPARγ2 on K107 site to potentiate adipogenesis and weaken osteogenesis. These results may provide new strategy and target in the clinical diagnosis and treatment of GIOP.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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