International Journal of Women's Health (Mar 2024)

Innovative Surgical Approaches That Improve Individual Outcomes in Advanced Breast Cancer

  • Luțenco V,
  • Rebegea L,
  • Beznea A,
  • Tocu G,
  • Moraru M,
  • Mihailov OM,
  • Ciuntu BM,
  • Luțenco V,
  • Stanculea FC,
  • Mihailov R

Journal volume & issue
Vol. Volume 16
pp. 555 – 560

Abstract

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Valerii Luțenco,1,* Laura Rebegea,2,3,* Adrian Beznea,1,3 George Tocu,3,* Monica Moraru,3 Oana Mariana Mihailov,3,* Bogdan Mihnea Ciuntu,4,* Verginia Luțenco,5 Floris Cristian Stanculea,6 Raul Mihailov1,3,* 1Surgery I Clinic, Emergency Hospital “Sf. Ap. Andrei”, Galați, Romania; 2Oncology and Radiotherapy Clinic, Emergency Hospital “Sf. Ap. Andrei”, Galați, Romania; 3“Dunărea de Jos” University of Galati, Faculty of Medicine and Pharmacy, Galați, Romania; 4“Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania; 5Clinical Children Emergency Hospital “Sf. Ioan”, Galați, Romania; 6“Carol Davila” University of Medicine and Pharmacy, Bucuresti, Romania*These authors contributed equally to this workCorrespondence: George Tocu; Oana Mariana Mihailov, “Dunarea de Jos” University of Galati, 47 Domneasca Street, Galați, 800008, Romania, Tel +40728249228 ; +40745250391, Email [email protected]; [email protected]: Breast cancer is the most common cause of cancer death in women and the second cause in the general population. The incidence has increased over time. Women in developing countries often present at an advanced stage where initial surgery is not feasible. Short disease-free intervals, the number of metastatic organs and liver metastasis were consistently associated with poor overall survival. Surgery is an integral part of the therapeutic plan for locally advanced breast cancer. The integration of surgical care into the management of patients with advanced cancer has changed substantially with the use of neoadjuvant chemotherapy. Also, more recently, neoadjuvant endocrine therapy and targeted therapies offer new opportunities to downsize the tumor burden and transform the role of surgery for this population from palliation to largely curative intent. Innovative surgical approach to the primary tumor in metastatic disease may provide survival benefits and local control in some patients. Similar to systemic therapy, surgical therapy for secondary dissemination should be considered in certain cases for improved individual outcomes. Advances in reconstructive techniques have improved the quality of life of these patients.Keywords: breast cancer, locally advanced, metastatic, individual outcomes, surgery

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