Nature Communications (Mar 2020)

Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor

  • Hirokazu Yagi,
  • Maho Yagi-Utsumi,
  • Rena Honda,
  • Yusaku Ohta,
  • Taiki Saito,
  • Miho Nishio,
  • Satoshi Ninagawa,
  • Kousuke Suzuki,
  • Takahiro Anzai,
  • Yukiko Kamiya,
  • Kazuhiro Aoki,
  • Mahito Nakanishi,
  • Tadashi Satoh,
  • Koichi Kato

DOI
https://doi.org/10.1038/s41467-020-15192-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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The secretion of blood coagulation factor V and factor VIII (FV and FVIII) are driven by secretion factors ERGIC-53 and MCDF2. Here, the authors report a 10 amino acid motif from FVIII that can enhance secretion of another glycoprotein erythropoietin (EPO).