Allergology International (Apr 2025)
Skin health survey on atopic dermatitis among Japanese children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
- Chikana Kawaguchi,
- Maki Ozawa,
- Takanori Hidaka,
- Keiko Murakami,
- Mami Ishikuro,
- Fumihiko Ueno,
- Aoi Noda,
- Tomomi Onuma,
- Genki Shinoda,
- Masatsugu Orui,
- Taku Obara,
- Yumiko Ito,
- Takashi Kakinuma,
- Kazuhiro Kudoh,
- Hiroaki Ozawa,
- Satoshi Nakagawa,
- Masato Mizuashi,
- Ryoko Omori,
- Masatoshi Deguchi,
- Yumi Kanbayashi,
- Masayuki Asano,
- Toshiya Takahashi,
- Muneo Tanita,
- Masahiro Hara,
- Kenshi Yamasaki,
- Takayoshi Tadaki,
- Hiromi Suzuki,
- Katsuko Kikuchi,
- Kenichiro Tsuchiyama,
- Takenobu Ohashi,
- Shu Sasai,
- Motoko Honda,
- Taku Fujimura,
- Sadanori Furudate,
- Yoshiko Kagimoto,
- Maki Kawamura,
- Nobuko Tabata,
- Rika Chikama,
- Hiromi Komatsu,
- Yota Sato,
- Kayo Tanita,
- Yutaka Kimura,
- Shino Yusa,
- Hitoshi Terui,
- Hisayuki Tono,
- Yusuke Muto,
- Shinichi Kuriyama,
- Masayuki Yamamoto,
- Setsuya Aiba
Affiliations
- Chikana Kawaguchi
- Department of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Miyagi, Japan
- Maki Ozawa
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Toshoguekimae Dermatology Clinic, Miyagi, Japan
- Takanori Hidaka
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan
- Keiko Murakami
- Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan; Corresponding author. Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8573, Japan.
- Mami Ishikuro
- Department of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan
- Fumihiko Ueno
- Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan
- Aoi Noda
- Department of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan; Department of Pharmaceutical Sciences, Tohoku University Hospital, Miyagi, Japan
- Tomomi Onuma
- Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan
- Genki Shinoda
- Department of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan
- Masatsugu Orui
- Department of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan
- Taku Obara
- Department of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan; Department of Pharmaceutical Sciences, Tohoku University Hospital, Miyagi, Japan
- Yumiko Ito
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan
- Takashi Kakinuma
- Sendai Aoba Dermatology Clinic, Miyagi, Japan
- Kazuhiro Kudoh
- Division of Dermatology, Katta General Hospital, Miyagi, Japan
- Hiroaki Ozawa
- Toshoguekimae Dermatology Clinic, Miyagi, Japan
- Satoshi Nakagawa
- Kitayobancho Nakagawa Dermatology Clinic, Miyagi, Japan
- Masato Mizuashi
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Rifu Dermatology Allergy Clinic, Miyagi, Japan
- Ryoko Omori
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan
- Masatoshi Deguchi
- Department of Dermatology, Shiogama City Hospital, Miyagi, Japan
- Yumi Kanbayashi
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan
- Masayuki Asano
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Nanohana Dermatology Clinic, Iwate, Japan
- Toshiya Takahashi
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan
- Muneo Tanita
- Department of Dermatology, Tohoku Rosai Hospital, Miyagi, Japan
- Masahiro Hara
- Izumi-chuo Hifuka Clinic, Miyagi, Japan
- Kenshi Yamasaki
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan
- Takayoshi Tadaki
- Minami Sendai Hifuka Clinic, Miyagi, Japan
- Hiromi Suzuki
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Arai Ekimae Suzuki Clinic, Miyagi, Japan
- Katsuko Kikuchi
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Sendai Taihaku Dermatology Clinic, Miyagi, Japan
- Kenichiro Tsuchiyama
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Natori Tsuchiyama Dermatology Clinic, Miyagi, Japan
- Takenobu Ohashi
- Familia Clinic Oroshimachi, Miyagi, Japan
- Shu Sasai
- Asuto-Nagamachi Dermatologic Clinic, Miyagi, Japan
- Motoko Honda
- Ichibancho Minami Shinryoujo Akane Clinic, Miyagi, Japan
- Taku Fujimura
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan
- Sadanori Furudate
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Division of Dermatology, Osaki Citizen Hospital, Miyagi, Japan
- Yoshiko Kagimoto
- Nami Dermatology Clinic, Miyagi, Japan
- Maki Kawamura
- Kawamura Dermatology Office, Miyagi, Japan
- Nobuko Tabata
- Division of Dermatology, Japanese Red Cross Sendai Hospital, Miyagi, Japan
- Rika Chikama
- Chikama Rika Dermatology Clinic, Miyagi, Japan
- Hiromi Komatsu
- Ciel Dermatology Clinic, Miyagi, Japan
- Yota Sato
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Division of Dermatology, Japanese Red Cross Ishinomaki Hospital, Miyagi, Japan
- Kayo Tanita
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan
- Yutaka Kimura
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Kimura Dermatology Clinic, Miyagi, Japan
- Shino Yusa
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Tagajo Ekimae Hifuka, Miyagi, Japan
- Hitoshi Terui
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan
- Hisayuki Tono
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Nanohana Dermatology Clinic, Iwate, Japan
- Yusuke Muto
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Department of Dermatology, South Miyagi Medical Centre, Miyagi, Japan
- Shinichi Kuriyama
- Department of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan; Department of Disaster Public Health, International Research Institute of Disaster Science, Tohoku University, Miyagi, Japan
- Masayuki Yamamoto
- Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan
- Setsuya Aiba
- Department of Dermatology, Graduate School of Medicine, Tohoku University, Miyagi, Japan; Matsuda Hospital, Miyagi, Japan
- DOI
- https://doi.org/10.1016/j.alit.2024.09.008
- Journal volume & issue
-
Vol. 74,
no. 2
pp. 246 – 253
Abstract
Background: Precise skin phenotypic data are indispensable in accurately diagnosing atopic dermatitis (AD). Therefore, this study examined the interobserver concordance for AD and non-AD diagnoses between two dermatologists. AD prevalence determined by the self-reported physician diagnoses and the diagnoses determined from the United Kingdom (UK) diagnostic criteria were compared with the diagnoses made by the two dermatologists, using data from a skin health survey. Methods: This study included 1,638 children that participated in the skin health survey, which was part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. AD was assessed using dermatologist assessments, self-reported physician diagnoses, and the UK diagnostic criteria. The concordance for diagnoses was evaluated using kappa. The sensitivity and specificity of the self-reported physician diagnoses and the UK diagnostic criteria were calculated by comparing them with the two dermatologists’ diagnoses. Results: Among the 1,638 children, 393 (24.0 %), 194 (11.9 %), and 597 (37.2 %) were diagnosed with AD by the two dermatologists, physicians, and the UK diagnostic criteria, respectively. The kappa (95 % CI) of the interobserver concordance for AD or non-AD diagnoses between the two dermatologists was 0.78 (0.75–0.81). The sensitivity and specificity of the self-reported physician diagnoses were 26.7 % and 94.1 %, respectively. The sensitivity and specificity of the UK diagnostic criteria were 85.0 % and 82.4 %, respectively. Conclusions: Interobserver concordance for AD or non-AD diagnoses between the two dermatologists was substantial. Self-reported physician diagnoses exhibited low sensitivity that potentially indicated underdiagnosis of AD, whereas the UK diagnostic criteria might overdiagnose AD.
Keywords
