Frontiers in Neurology (Feb 2023)

Effect of botulinum toxin type A on non-motor symptoms and quality of life in Meige syndrome

  • Heqing Zheng,
  • Lanxiang Wu,
  • Sheng Tian,
  • Mingxu Liu,
  • Qingqing Zhan,
  • Xinping Yu,
  • Yonggang Xie,
  • Xianhui Zhong,
  • Wei Wu

DOI
https://doi.org/10.3389/fneur.2023.1115482
Journal volume & issue
Vol. 14

Abstract

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BackgroundIt has been shown in previous studies that botulinum toxin type A (BTX-A) can effectively relieve the motor symptoms of Meige syndrome. However, its effect on non-motor symptoms (NMS) and quality of life (QoL) has not been comprehensively studied. This study aimed to explore the effects of BTX-A on NMS and QoL and to clarify the relationship between changes in motor symptoms, NMS, and QoL after BTX-A.MethodsSeventy-five patients were recruited for the study. All patients were assessed by a series of clinical assessments before, one, and 3 months after BTX-A treatment. Dystonic symptoms, psychiatric disturbances, sleep disorders, and QoL were evaluated.ResultsAfter 1 and 3 months of BTX-A treatment, the scores of motor symptoms, anxiety, and depression were significantly decreased (P < 0.05). Except for general health, the scores of the other 36-item short-form health survey QoL subitems were significantly improved after BTX-A (P < 0.05). After 1 month of treatment, the changes in anxiety and depression were not correlated with changes in motor symptoms (P > 0.05). Still, they were negatively correlated with changes in physical functioning, role-physical and mental component summary QoL (P < 0.05).ConclusionsBTX-A effectively improved motor symptoms, anxiety, depression, and QoL. Anxiety and depression improvement did not correlate with motor symptom changes after BTX-A, and QoL improvements were strongly associated with psychiatric disturbances.

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