Linking DNA repair and cell cycle progression through serine ADP-ribosylation of histones

Julien Brustel; Tetsuya Muramoto; Kazuki Fumimoto; Jessica Ellins; Catherine J. Pears; Nicholas D. Lakin

doi:10.1038/s41467-021-27867-4

Nature Communications (Jan 2022)

Linking DNA repair and cell cycle progression through serine ADP-ribosylation of histones

Julien Brustel,
Tetsuya Muramoto,
Kazuki Fumimoto,
Jessica Ellins,
Catherine J. Pears,
Nicholas D. Lakin

Affiliations

Julien Brustel: Department of Biochemistry, University of Oxford
Tetsuya Muramoto: Department of Biology, Faculty of Science, Toho University
Kazuki Fumimoto: Department of Biology, Faculty of Science, Toho University
Jessica Ellins: Department of Biochemistry, University of Oxford
Catherine J. Pears: Department of Biochemistry, University of Oxford
Nicholas D. Lakin: Department of Biochemistry, University of Oxford

DOI: https://doi.org/10.1038/s41467-021-27867-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Poly(ADP-ribose)-polymerases (PARPs) are a cornerstone of the DNA damage response that promote DNA repair by modifying target proteins with ADP-ribose. Here, the authors show serine ADP-ribosylation of the H3 variant H3b maintains genome stability by coupling DNA repair with mitotic entry in Dictyostelium by regulating double strand break repair by nonhomologous end-joining (NHEJ).

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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