Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study.

Abstract

BackgroundCreatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA1C) in a nondiabetic general population.MethodsAssociations between CK and the outcome variable HbA1C (%) were performed by variance and multivariate analyses in 11662 nondiabetic subjects defined as HbA1C (%) ResultsAbnormal elevated CK was detected in 543/11662 participants (4.66%). Mean HbA1C (%) in the "high CK" group was 5.62 (SD = 0.33) compared to 5.52 (SD = 0.36) in the "normal CK" group, P ConclusionThese data demonstrate a positive and independent association between CK and glycated haemoglobin in a nondiabetic general population.