Nature Communications (Dec 2018)
Honey bee Royalactin unlocks conserved pluripotency pathway in mammals
- Derrick C. Wan,
- Stefanie L. Morgan,
- Andrew L. Spencley,
- Natasha Mariano,
- Erin Y. Chang,
- Gautam Shankar,
- Yunhai Luo,
- Ted H. Li,
- Dana Huh,
- Star K. Huynh,
- Jasmine M. Garcia,
- Cole M. Dovey,
- Jennifer Lumb,
- Ling Liu,
- Katharine V. Brown,
- Abel Bermudez,
- Richard Luong,
- Hong Zeng,
- Victoria L. Mascetti,
- Sharon J. Pitteri,
- Jordon Wang,
- Hua Tu,
- Marco Quarta,
- Vittorio Sebastiano,
- Roel Nusse,
- Thomas A. Rando,
- Jan E. Carette,
- J. Fernando Bazan,
- Kevin C. Wang
Affiliations
- Derrick C. Wan
- Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine
- Stefanie L. Morgan
- Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine
- Andrew L. Spencley
- Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine
- Natasha Mariano
- Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine
- Erin Y. Chang
- Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine
- Gautam Shankar
- Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine
- Yunhai Luo
- Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine
- Ted H. Li
- Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine
- Dana Huh
- Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine
- Star K. Huynh
- Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine
- Jasmine M. Garcia
- Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine
- Cole M. Dovey
- Department of Microbiology and Immunology, Stanford University School of Medicine
- Jennifer Lumb
- Department of Microbiology and Immunology, Stanford University School of Medicine
- Ling Liu
- The Glenn Laboratories for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine
- Katharine V. Brown
- Department of Developmental Biology, Howard Hughes Medical Institute, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Abel Bermudez
- Canary Center for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine
- Richard Luong
- Department of Comparative Medicine, Stanford University School of Medicine
- Hong Zeng
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Victoria L. Mascetti
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Sharon J. Pitteri
- Canary Center for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine
- Jordon Wang
- LakePharma, Inc.
- Hua Tu
- LakePharma, Inc.
- Marco Quarta
- The Glenn Laboratories for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine
- Vittorio Sebastiano
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Roel Nusse
- Department of Developmental Biology, Howard Hughes Medical Institute, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Thomas A. Rando
- The Glenn Laboratories for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine
- Jan E. Carette
- Department of Microbiology and Immunology, Stanford University School of Medicine
- J. Fernando Bazan
- R&D Systems, Inc
- Kevin C. Wang
- Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-06256-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
Royal jelly is the queen-maker for the honey bee that also has effects on longevity, fertility, and regeneration in mammals. Here the authors provide evidence that its major protein component Royalactin, and the mammalian structural analog Regina, maintain pluripotency in mouse ESCs by activating a ground-state pluripotency-like gene network.
