Fibrotic microtissue array to predict anti-fibrosis drug efficacy

Mohammadnabi Asmani; Sanjana Velumani; Yan Li; Nicole Wawrzyniak; Isaac Hsia; Zhaowei Chen; Boris Hinz; Ruogang Zhao

doi:10.1038/s41467-018-04336-z

Nature Communications (May 2018)

Fibrotic microtissue array to predict anti-fibrosis drug efficacy

Mohammadnabi Asmani,
Sanjana Velumani,
Yan Li,
Nicole Wawrzyniak,
Isaac Hsia,
Zhaowei Chen,
Boris Hinz,
Ruogang Zhao

Affiliations

Mohammadnabi Asmani: Department of Biomedical Engineering, University at Buffalo, The State University of New York
Sanjana Velumani: Department of Biomedical Engineering, University at Buffalo, The State University of New York
Yan Li: Department of Biomedical Engineering, University at Buffalo, The State University of New York
Nicole Wawrzyniak: Department of Biomedical Engineering, University at Buffalo, The State University of New York
Isaac Hsia: Department of Biomedical Engineering, University at Buffalo, The State University of New York
Zhaowei Chen: Department of Biomedical Engineering, University at Buffalo, The State University of New York
Boris Hinz: Laboratory of Tissue Repair and Regeneration, Matrix Dynamics Group, Faculty of Dentistry, University of Toronto
Ruogang Zhao: Department of Biomedical Engineering, University at Buffalo, The State University of New York

DOI: https://doi.org/10.1038/s41467-018-04336-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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A bottleneck in developing new anti-fibrosis therapies is the absence of suitable in vitro models that recapitulate key features of fibrogenesis. Here the authors develop a tissue-on-a-chip model of lung fibrosis and test the therapeutic efficacy of two recent FDA-approved drugs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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