Nature Communications (Aug 2019)

MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex

  • Benjamin Gottschalk,
  • Christiane Klec,
  • Gerd Leitinger,
  • Eva Bernhart,
  • René Rost,
  • Helmut Bischof,
  • Corina T. Madreiter-Sokolowski,
  • Snježana Radulović,
  • Emrah Eroglu,
  • Wolfgang Sattler,
  • Markus Waldeck-Weiermair,
  • Roland Malli,
  • Wolfgang F. Graier

DOI
https://doi.org/10.1038/s41467-019-11692-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

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Proper mitochondrial structure is critical for normal function. Here, the authors show with SIM that the mitochondrial Ca2+ uniporter complex and localization of component MICU1 is critical to maintaining cristae junction stability and overall mitochondrial membrane structure.