Hypoglycemic of Cajanus scarabaeoides in glucose overloaded and streptozotocin-induced diabetic rats

Abstract

In light of traditional claim of Cajanus scarabaeoides (L) in the treatment of diabetes, we studied the effects of different solvent extracts in normal, glucose over loaded normal and streptozotocin-induced diabetic rats. The methanolic extract (500 mg/kg orally) was produce significantly reduce blood glucose level at normal, glucose over loaded normal rats, and streptozotocin-induced diabetic rats 15 days treatment whereas petroleum ether and chloroform extract (500 mg/kg orally) did not exhibit any significant effect on three groups of rats. Histopathology studies on pancreas streptozotocin-induced diabetic rats inflammatory changes were detected in pancreatic islets results from selectively destroy of insulin producing beta-cells. These changes are inhibited by C. scarabaeoides methanolic extract and gliclazide. The antidiabetic activity of methanolic extract may be due to the presence of flavonoids.

Keywords

• Cajanus scarabaeoides
• Diabetes mellitus
• Hypoglycemic
• Streptozotocin