Implementation of Monte Carlo based PET verification of ion beam delivery into a TPS

Pablo Yepes; Zhuangming Shen; Michael F. Moyers; Qianxia Wang; Hongliang Chen; Jie Li; Yongqiang Li; James Lin

Radiation Medicine and Protection (Sep 2022)

Implementation of Monte Carlo based PET verification of ion beam delivery into a TPS

Pablo Yepes,
Zhuangming Shen,
Michael F. Moyers,
Qianxia Wang,
Hongliang Chen,
Jie Li,
Yongqiang Li,
James Lin

Affiliations

Pablo Yepes: Rice University, Houston, TX, 77005, USA
Zhuangming Shen: Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201315, China
Michael F. Moyers: Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201315, China; Corresponding author.
Qianxia Wang: Rice University, Houston, TX, 77005, USA
Hongliang Chen: Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201315, China
Jie Li: Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201315, China
Yongqiang Li: Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201315, China
James Lin: Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201315, China

Journal volume & issue: Vol. 3, no. 3
pp. 131 – 138

Abstract

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Objective: To develop and implement an ion beam teletherapy verification system based upon simulations of induced radioactivity and comparison with patient positron emission tomography (PET) scans. Methods: A Monte Carlo algorithm was integrated into an in-house built treatment, information, management, and planning system (TIMPS®) to calculate distributions of positron emitters induced by ion beams. These distributions are processed to simulate PET images taking into account positron diffusion, radioactive decay, biological washout, and detector blurring. Additional tools were developed to register simulated PET images with planning CT images and perform comparisons of measured and simulated PET images. Results: Production cross-sections were generated for various isotopes and materials. Treatment plans for several different body sites were used to verify the functioning and utility of the new tools for both proton and carbon ion beams. Conclusions: Several tools have been developed to simulate PET scans of patients irradiated with ion beams and compare the simulated images to measurements. After commissioning and implementation into the clinic, the appropriate sizes for margins that account for uncertainties may be investigated.

Published in Radiation Medicine and Protection

ISSN: 2666-5557 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiation-medicine-and-protection

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