Anti-trypanosomal Activity of Potential Inhibitors of Trypanosoma brucei Glycolytic Pathway Enzymes Selected by Docking Studies

Abstract

Human African trypanosomiasis (HAT), a potentially fatal protozoan infection caused by tsetse-fl mediated transmission of Trypanosoma brucei (T. Brucei), is largely recognized as a neglected disease. The repertoire of drugs that is effective against the infection is limited and all drugs have several drawbacks including high level of toxicity, diffiult administration regimens, and the resurgence of resistance. At present the biology of the parasite is well studied and a number of technologies are now available which can aid in the identifiation of potential drug targets. This review identifies putative inhibitors of trypanosomal glycolytic enzymes.

Keywords

• Human African trypanosomiasis
• Trypanosoma brucei
• glycolytic pathway enzymes