Study of serum antioxidant levels in patients with acute lymphocytic leukemia and chronic myelocytic leukemia before and after vincristine intake

Abstract

ABSTRACT The study included the determination of the antioxidants levels of acute lymphocytic leukemia and chronic myelocytic leukemia patients in Mosul city (Before and after taking vincristine (Chemical drug)). The investigated antioxidants were: glutathione (GSH), uric acid, ceruloplasmin (Cp.), vitamin E, vitamin C and malondialdehyde (MDA). Acute lymphocytic leukemia (29) and chronic myelocytic leukemia (31) and control group of the same age in each group (43) included in the research . The results showed that there were a significant decrease (P Moreover the (GSH, vitamin E and vitamin C) levels were increased significantly and the level of uric acid, Cp. and MDA decreased significantly (P<0.0001) in acute lymphocytic leukemia and chronic myelocytic leukemia patients as in comparison with its counter part before and after drug intake.

Keywords

• antioxidant levels
• lymphocytic leukemia
• myelocytic leukemia
• vincristine