Efficacy and Safety of a Natural Supplement Containing Serenoa Repens, Solanum Lycopersicum, Lycopene, and Bromelain in Reducing Symptoms of Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Prospective Cohort Study in 250 Patients
Luca Lambertini,
Alessandro Sandulli,
Vincenzo Salamone,
Mara Bacchiani,
Sofia Giudici,
Eleana Massaro,
Anna Cadenar,
Riccardo Mariottini,
Simone Coco,
Laia Bardina,
Elena Ciaralli,
Marco Saladino,
Andrea Romano,
Francesca Valastro,
Antonio Andrea Grosso,
Fabrizio Di Maida,
Giampaolo Siena,
Sabino Scelzi,
Andrea Mari
Affiliations
Luca Lambertini
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Alessandro Sandulli
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Vincenzo Salamone
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Mara Bacchiani
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Sofia Giudici
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Eleana Massaro
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Anna Cadenar
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Riccardo Mariottini
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Simone Coco
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Laia Bardina
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Elena Ciaralli
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Marco Saladino
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Andrea Romano
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Francesca Valastro
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Antonio Andrea Grosso
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Fabrizio Di Maida
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Giampaolo Siena
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Sabino Scelzi
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Andrea Mari
Unit of Urological Oncologic Minimally Invasive Robotic Surgery and Andrology, University of Florence, Careggi Hospital, 50134 Florence, Italy
Background: Chronic Prostatitis/Chronic Pelvic Pain syndrome NIH-class III is a widespread condition affecting men universally, with existing treatments showing limited success. This study evaluated the efficacy and safety of a natural supplement, composed of Serenoa repens, Solanum lycopersicum, lycopene, and bromelain, in managing symptoms of this condition among a substantial patient group. Methods: In this prospective study, 245 patients diagnosed with Chronic Prostatitis/Chronic Pelvic Pain syndrome NIH-class III were treated with the aforementioned supplement, alongside lifestyle alterations, such as refraining from spicy foods, alcohol, caffeine, and cycling, for a duration of three months. Patients’ progress was assessed at one and three months using the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), the International Prostate Symptom Index (IPSS), quality of life (QoL) scores, and changes in total prostate-specific antigen (PSA) levels. Results: The supplement was well received with no serious adverse events reported. Significant improvements were observed in NIH-CPSI scores, IPSS, QoL scores, and a substantial decrease in total PSA levels at three months compared to baseline, with a positive trend noted from one-month to three-month evaluations. This was consistent in either patients with predominantly voiding or storage urinary symptoms. Conclusions: Our results suggest that this natural supplement in conjunction with lifestyle changes could offer a safe and effective alternative treatment for patients suffering from Chronic Prostatitis/Chronic Pelvic Pain syndrome NIH-class III. However, these findings require validation through further large-scale randomized controlled trials.
