Nature Communications (Dec 2019)

PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression

  • Yaw-Dong Lang,
  • Hsin-Yi Chen,
  • Chun-Ming Ho,
  • Jou-Ho Shih,
  • En-Chi Hsu,
  • Roger Shen,
  • Yu-Ching Lee,
  • Jyun-Wei Chen,
  • Cheng-Yen Wu,
  • Hsi-Wen Yeh,
  • Ruey-Hwa Chen,
  • Yuh-Shan Jou

DOI
https://doi.org/10.1038/s41467-019-13665-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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PSPC1 has a critical role in promoting EMT and metastasis. Here, the authors demonstrate that PSPC1 is the contextual determinant of the oncogenic switch of PTK6/β-catenin subcellular localizations to drive metastasis of hepatocellular carcinoma cells via a PSPC1/PTK6/β-catenin signaling.