TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response

Zhenzhong Ma; Tong Zang; Shari G. Birnbaum; Zilai Wang; Jane E. Johnson; Chun-Li Zhang; Luis F. Parada

doi:10.1038/s41467-017-01709-8

Nature Communications (Nov 2017)

TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response

Zhenzhong Ma,
Tong Zang,
Shari G. Birnbaum,
Zilai Wang,
Jane E. Johnson,
Chun-Li Zhang,
Luis F. Parada

Affiliations

Zhenzhong Ma: Department of Developmental Biology & Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center
Tong Zang: Department of Molecular Biology, University of Texas Southwestern Medical Center
Shari G. Birnbaum: Department of Psychiatry, University of Texas Southwestern Medical Center
Zilai Wang: Department of Developmental Biology & Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center
Jane E. Johnson: Department of Neuroscience, University of Texas Southwestern Medical Center
Chun-Li Zhang: Department of Molecular Biology, University of Texas Southwestern Medical Center
Luis F. Parada: Department of Developmental Biology & Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-017-01709-8
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

The precise mechanism for the sustained antidepressant action of ketamine is unclear. This study shows ketamine can promote neuronal differentiation via TrkB-ERK activation in mice and the sustained behavioral effect is attenuated when adult neurogenesis is blocked, but extended when it is enhanced.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal