Nature Communications (May 2019)
Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy
- Carlota Dobaño,
- Hèctor Sanz,
- Hermann Sorgho,
- David Dosoo,
- Maximilian Mpina,
- Itziar Ubillos,
- Ruth Aguilar,
- Tom Ford,
- Núria Díez-Padrisa,
- Nana Aba Williams,
- Aintzane Ayestaran,
- Ousmane Traore,
- Augusto J. Nhabomba,
- Chenjerai Jairoce,
- John Waitumbi,
- Selidji Todagbe Agnandji,
- Simon Kariuki,
- Salim Abdulla,
- John J. Aponte,
- Benjamin Mordmüller,
- Kwaku Poku Asante,
- Seth Owusu-Agyei,
- Halidou Tinto,
- Joseph J. Campo,
- Gemma Moncunill,
- Ben Gyan,
- Clarissa Valim,
- Claudia Daubenberger
Affiliations
- Carlota Dobaño
- ISGlobal, Hospital Clínic - Universitat de Barcelona
- Hèctor Sanz
- ISGlobal, Hospital Clínic - Universitat de Barcelona
- Hermann Sorgho
- Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé
- David Dosoo
- Kintampo Health Research Centre
- Maximilian Mpina
- Ifakara Health Institute, Bagamoyo Research and Training Centre
- Itziar Ubillos
- ISGlobal, Hospital Clínic - Universitat de Barcelona
- Ruth Aguilar
- ISGlobal, Hospital Clínic - Universitat de Barcelona
- Tom Ford
- IAVI - Human Immunology Laboratory, Imperial College
- Núria Díez-Padrisa
- ISGlobal, Hospital Clínic - Universitat de Barcelona
- Nana Aba Williams
- ISGlobal, Hospital Clínic - Universitat de Barcelona
- Aintzane Ayestaran
- ISGlobal, Hospital Clínic - Universitat de Barcelona
- Ousmane Traore
- Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé
- Augusto J. Nhabomba
- Centro de Investigação em Saúde de Manhiça (CISM)
- Chenjerai Jairoce
- Centro de Investigação em Saúde de Manhiça (CISM)
- John Waitumbi
- US Army Medical Research Directorate-Kenya, Walter Reed Army Institute of Research/Kenya Medical Research Institute
- Selidji Todagbe Agnandji
- Centre de Recherches Médicales de Lambaréné (CERMEL)
- Simon Kariuki
- Kenya Medical Research Institute/Centre for Global Health
- Salim Abdulla
- Ifakara Health Institute, Bagamoyo Research and Training Centre
- John J. Aponte
- ISGlobal, Hospital Clínic - Universitat de Barcelona
- Benjamin Mordmüller
- Institute of Tropical Medicine and German Center for Infection Research, University of Tübingen
- Kwaku Poku Asante
- Kintampo Health Research Centre
- Seth Owusu-Agyei
- Kintampo Health Research Centre
- Halidou Tinto
- Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé
- Joseph J. Campo
- ISGlobal, Hospital Clínic - Universitat de Barcelona
- Gemma Moncunill
- ISGlobal, Hospital Clínic - Universitat de Barcelona
- Ben Gyan
- Kintampo Health Research Centre
- Clarissa Valim
- Department of Osteopathic Medical Specialties, Michigan State University
- Claudia Daubenberger
- Swiss Tropical and Public Health Institute
- DOI
- https://doi.org/10.1038/s41467-019-10195-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
RTS,S/AS01E has been tested in a phase 3 malaria vaccine trial and has shown partial efficacy in children and infants. Here, the authors analyze IgG concentration and avidity to CSP in ~1000 participants and show that IgG avidity to the C-terminus of CSP is significantly associated with vaccine-mediated protection.
