Nature Communications (Oct 2022)
Autophagy induction promoted by m6A reader YTHDF3 through translation upregulation of FOXO3 mRNA
- WeiChao Hao,
- MeiJuan Dian,
- Ying Zhou,
- QiuLing Zhong,
- WenQian Pang,
- ZiJian Li,
- YaYan Zhao,
- JiaCheng Ma,
- XiaoLin Lin,
- RenRu Luo,
- YongLong Li,
- JunShuang Jia,
- HongFen Shen,
- ShiHao Huang,
- GuanQi Dai,
- JiaHong Wang,
- Yan Sun,
- Dong Xiao
Affiliations
- WeiChao Hao
- Department of Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University
- MeiJuan Dian
- Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University
- Ying Zhou
- Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University
- QiuLing Zhong
- Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University
- WenQian Pang
- Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University
- ZiJian Li
- Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University
- YaYan Zhao
- Department of Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University
- JiaCheng Ma
- Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University
- XiaoLin Lin
- Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University
- RenRu Luo
- School of Medicine, Shenzhen Campus of Sun Yat-sen University
- YongLong Li
- Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University
- JunShuang Jia
- Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University
- HongFen Shen
- Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University
- ShiHao Huang
- Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University
- GuanQi Dai
- Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University
- JiaHong Wang
- Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University
- Yan Sun
- Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences
- Dong Xiao
- Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University
- DOI
- https://doi.org/10.1038/s41467-022-32963-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 23
Abstract
The role of eiptranscriptomic modifications in autophagy is unclear. Here, the authors show that the m6A reader YTHDF3 functions as a nutrient responder to recognize upregulated m6A modification, promoting FOXO3 translation to subsequently initiate autophagy.
