Some aspects of genetic control of antibiotic biosynthesis in Streptomyces

Abstract

These work contain a review of basic hypotheses and experimental information in relation to the problem of antibiotic synthesis regulation by the bacteria of the Streptomyces family. Data on cluster organization of antibiotics biosynthesis genes in these microorganisms were generalized. The examples of the positive and negative specific control of antibiotic production genes were resulted. Except for it, proofs that confirm participation of a few genes of more high level in the process of initiation and expression of antibiotics biosynthesis genes also were found. In this connection А-factor role in the mechanism of cascade-organized process of streptomycin biosynthesis control, some other antibiotics and spore determinations is discussed in detail.