Role of Laboratory Parameters in the Diagnosis of OMI/NOMI

Abstract

Aim: The occlusion myocardial infarction (OMI) and non-OMI (NOMI) paradigms aim to improve the quality to ensure effective diagnosis and treatment. Due to the lack of universally accepted diagnostic criteria, the study aimed to investigate the correlation between laboratory parameters commonly analyzed in the emergency department in patients with and non-segment elevation myocardial infarction and OMI/NOMI definitions. Materials and Methods: Demographic characteristics, mortality status, laboratory parameters and thrombolysis in MI (TIMI) scores of patients were recorded. Patients with TIMI scores of 0-2 and 3 were considered OMI and NOMI. Findings were considered significant when p<0.05. Results: In 107 patients, white blood cell value was 10.3 (8.30-2.8) and neutrophil was 7.30 (5.45-10.0) in the OMI group (p values=0.023, 0.008). The median troponin was 0.68 (0.15-4.82), C-reactive protein (CRP) was 11.8 (4.3-26.5), in the OMI group (p=0.014, 0.004). Upon logistic regression analysis, the neutrophil was independent in OMI/NOMI discrimination. The effectiveness of neutrophil in determining OMI, sensitivity, specificity, positive predictive value, and negative predictive value were 82.69%, 40.00%, 56.58%, and 70.97%, respectively (area under the curve: 0.650), when the neutrophil was set to 5.1 × 109/L. Conclusion: Neutrophil level can be considered an independent variable for the differentiation of OMI/NOMI patients. Troponin and CRP values significantly differ between these two groups.

Keywords

• acute coronary syndrome
• biomarkers
• coronary occlusion
• myocardial infarction