Nature Communications (Apr 2019)
Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma
- Ting Yan,
- Heyang Cui,
- Yong Zhou,
- Bin Yang,
- Pengzhou Kong,
- Yingchun Zhang,
- Yiqian Liu,
- Bin Wang,
- Yikun Cheng,
- Jiayi Li,
- Shixing Guo,
- Enwei Xu,
- Huijuan Liu,
- Caixia Cheng,
- Ling Zhang,
- Ling Chen,
- Xiaofei Zhuang,
- Yu Qian,
- Jian Yang,
- Yanchun Ma,
- Hongyi Li,
- Fang Wang,
- Jing Liu,
- Xuefeng Liu,
- Dan Su,
- Yan Wang,
- Ruifang Sun,
- Shiping Guo,
- Yaoping Li,
- Xiaolong Cheng,
- Zhihua Liu,
- Qimin Zhan,
- Yongping Cui
Affiliations
- Ting Yan
- Shenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen Hospital
- Heyang Cui
- Shenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen Hospital
- Yong Zhou
- Shenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen Hospital
- Bin Yang
- Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical University
- Pengzhou Kong
- Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical University
- Yingchun Zhang
- Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical University
- Yiqian Liu
- Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical University
- Bin Wang
- Shenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen Hospital
- Yikun Cheng
- College of Letter & Science, University of California Berkeley
- Jiayi Li
- Anglo-Chinese School (Independent)
- Shixing Guo
- Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical University
- Enwei Xu
- Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical University
- Huijuan Liu
- Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical University
- Caixia Cheng
- Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical University
- Ling Zhang
- Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical University
- Ling Chen
- Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics, Nankai University Gynecology Obstetrics Hospital
- Xiaofei Zhuang
- Department of Tumor Surgery, Shanxi Cancer Hospital
- Yu Qian
- Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical University
- Jian Yang
- Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical University
- Yanchun Ma
- Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical University
- Hongyi Li
- Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical University
- Fang Wang
- Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical University
- Jing Liu
- Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical University
- Xuefeng Liu
- Shenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen Hospital
- Dan Su
- Department of Pathology, Zhejiang Cancer Hospital
- Yan Wang
- Shenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen Hospital
- Ruifang Sun
- Tumor Biobank, Shanxi Cancer Hospital
- Shiping Guo
- Department of Tumor Surgery, Shanxi Cancer Hospital
- Yaoping Li
- Department of Colorectal & Anal Surgery, Affiliated Provincial Hospital of Shanxi Medical University
- Xiaolong Cheng
- Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical University
- Zhihua Liu
- State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Qimin Zhan
- Shenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen Hospital
- Yongping Cui
- Shenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen Hospital
- DOI
- https://doi.org/10.1038/s41467-019-09255-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Esophageal squamous cell carcinoma (ESCC) is highly prevalent in China. Here, the authors carry out multi-region sampling of Chinese ESCC samples, and find recurrent ERBB4 mutations, BRCA1/2 variants, and amplification of CD274; together with high levels of genomic and T-cell receptor heterogeneity.
