Cell-type-specific genomics reveals histone modification dynamics in mammalian meiosis

Kwan-Wood Gabriel Lam; Kevin Brick; Gang Cheng; Florencia Pratto; R. Daniel Camerini-Otero

doi:10.1038/s41467-019-11820-7

Nature Communications (Aug 2019)

Cell-type-specific genomics reveals histone modification dynamics in mammalian meiosis

Kwan-Wood Gabriel Lam,
Kevin Brick,
Gang Cheng,
Florencia Pratto,
R. Daniel Camerini-Otero

Affiliations

Kwan-Wood Gabriel Lam: Genetics and Biochemistry Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health
Kevin Brick: Genetics and Biochemistry Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health
Gang Cheng: Genetics and Biochemistry Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health
Florencia Pratto: Genetics and Biochemistry Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health
R. Daniel Camerini-Otero: Genetics and Biochemistry Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health

DOI: https://doi.org/10.1038/s41467-019-11820-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Meiotic DSB formation, repair and recombination occur in a continuum of substages termed leptonema, zygonema, pachynema, and diplonema. Here, authors develop a method for isolating pure sub-populations of nuclei that allows for detailed study of meiotic substages.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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