Nature Communications (Jan 2025)

A reagent to access methyl sulfones

  • Yaroslav Poplavskyi,
  • Vasyl Ripenko,
  • Sergei Bova,
  • Angelina Biitseva,
  • Yurii V. Dmitriv,
  • Andrei A. Tolmachev,
  • Iryna V. Sadkova,
  • Iryna Pishel,
  • Oleksii Grygorov,
  • Vo Quang Huy Phan,
  • H. V. Rasika Dias,
  • Pavel K. Mykhailiuk

DOI
https://doi.org/10.1038/s41467-024-55027-x
Journal volume & issue
Vol. 16, no. 1
pp. 1 – 10

Abstract

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Abstract A chemical reagent to access methyl sulfones has been developed. Its reaction with various bis-nucleophiles leads to the rapid formation of previously unknown heteroaromatic methyl sulfones. Analogous strategy can also be used to construct alkyl-, CHF2-, CF3- and even bicyclo[1.1.1]pentane-containing derivatives. These compounds have been demonstrated to have a high potential for use in medicinal chemistry and coordination chemistry.