Nature Communications (Apr 2022)

A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2

  • Yingna Xu,
  • Wenbo Feng,
  • Qingtong Zhou,
  • Anyi Liang,
  • Jie Li,
  • Antao Dai,
  • Fenghui Zhao,
  • Jiahui Yan,
  • Chuan-Wei Chen,
  • Hao Li,
  • Li-Hua Zhao,
  • Tian Xia,
  • Yi Jiang,
  • H. Eric Xu,
  • Dehua Yang,
  • Ming-Wei Wang

DOI
https://doi.org/10.1038/s41467-022-30041-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 10

Abstract

Read online

Vasoactive intestinal polypeptide receptor 2 (VIP2R) is involved in immunity. Here, the authors report two cryo-EM structures of the VIP2R–Gs in complex with the endogenous peptide ligand PACAP27, revealing a unique interaction mode between PACAP27 and the receptor, stabilized by the N-terminal α-helix of VIP2R.