Nature Communications (Oct 2016)

An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid

  • Vanessa K. Wong,
  • Stephen Baker,
  • Thomas R. Connor,
  • Derek Pickard,
  • Andrew J. Page,
  • Jayshree Dave,
  • Niamh Murphy,
  • Richard Holliman,
  • Armine Sefton,
  • Michael Millar,
  • Zoe A. Dyson,
  • Gordon Dougan,
  • Kathryn E. Holt,
  • International Typhoid Consortium

DOI
https://doi.org/10.1038/ncomms12827
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 11

Abstract

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Typhoid fever is caused by Salmonella enterica serovar Typhi (S. Typhi). This study examines ∼2,000 clinical isolates of S. Typhi to show highly structured/geographically restricted genomes except rapidly disseminating H58 subclade, and design a genotyping framework for tracking the disease.