Paralysis of the cytotoxic granule machinery is a new cancer immune evasion mechanism mediated by chitinase 3-like-1

• Giuseppe Curigliano,
• Sebastian Kobold,
• Maria Rescigno,
• Juliette Mouriès,
• Giuseppe Penna,
• Alessia Melacarne,
• Abbass Darwich,
• Alessandra Silvestri,
• Mohamed-Reda Benmebarek,
• Bruno Cadilha,
• Lapo Morelli,
• Domenico Supino,
• Alexandre Taleb,
• Hannah Obeck,
• Claudio Sustmann,
• Agnese Losurdo,
• Giovanna Masci

Affiliations

Giuseppe Curigliano

European Institute of Oncology (IEO), IRCCS, Milan, Italy

Sebastian Kobold

Division of Clinical Pharmacology, Ludwig-Maximilians-Universitat Munchen, Munich, UK

Maria Rescigno

Department of Biomedical Sciences, Humanitas University, Milan, Italy

Juliette Mouriès

Department of Biomedical Sciences, Humanitas University, Milan, Italy

Giuseppe Penna

IRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, Milan, Italy

Alessia Melacarne

IRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, Milan, Italy

Abbass Darwich

Department of Biomedical Sciences, Humanitas University, Milan, Italy

Alessandra Silvestri

IRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, Milan, Italy

Mohamed-Reda Benmebarek

Department of Medicine IV, Ludwig-Maximilians-Universitat Munchen, Munchen, Bayern, Germany

Bruno Cadilha

Division for Clinical Pharmacology, Ludwig-Maximilians-Universitat Munchen, Munich, Germany

Lapo Morelli

European Institute of Oncology, IRCCS, Milano, Italy

Domenico Supino

Department of Biomedical Sciences, Humanitas University, Milan, Italy

Alexandre Taleb

Roche Innovation Center Munich, Penzberg, Germany

Hannah Obeck

Department of Medicine IV, Ludwig-Maximilians-Universitat Munchen, Munchen, Bayern, Germany

Claudio Sustmann

Roche Innovation Center Munich, Penzberg, Germany

Agnese Losurdo

IRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, Milan, Italy

Giovanna Masci

IRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, Milan, Italy