Nature Communications (Dec 2018)
Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin
- Eileen McNeill,
- Elena Stylianou,
- Mark J. Crabtree,
- Rachel Harrington-Kandt,
- Anna-Lena Kolb,
- Marina Diotallevi,
- Ashley B. Hale,
- Paulo Bettencourt,
- Rachel Tanner,
- Matthew K. O’Shea,
- Magali Matsumiya,
- Helen Lockstone,
- Julius Müller,
- Helen A. Fletcher,
- David R. Greaves,
- Helen McShane,
- Keith M. Channon
Affiliations
- Eileen McNeill
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford
- Elena Stylianou
- Jenner Institute, University of Oxford
- Mark J. Crabtree
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford
- Rachel Harrington-Kandt
- Jenner Institute, University of Oxford
- Anna-Lena Kolb
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford
- Marina Diotallevi
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford
- Ashley B. Hale
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford
- Paulo Bettencourt
- Jenner Institute, University of Oxford
- Rachel Tanner
- Jenner Institute, University of Oxford
- Matthew K. O’Shea
- Jenner Institute, University of Oxford
- Magali Matsumiya
- Jenner Institute, University of Oxford
- Helen Lockstone
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Julius Müller
- Jenner Institute, University of Oxford
- Helen A. Fletcher
- Department of Immunology and Infection, London School of Hygiene and Tropical Medicine
- David R. Greaves
- Sir William Dunn School of Pathology, University of Oxford
- Helen McShane
- Jenner Institute, University of Oxford
- Keith M. Channon
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-018-07714-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Inducible nitric oxide (NO) synthase (iNOS) is essential in the response to mycobacterial infection, yet NOS signalling can occur through NO-dependent or NO-independent pathways. Here the authors show macrophage Gch1 and tetrahydrobiopterin mediate NO-independent control of Mycobacterial infection.
