Frontiers in Physiology (Jan 2021)

Simulating Dynamics of Circulation in the Awake State and Different Stages of Sleep Using Non-autonomous Mathematical Model With Time Delay

  • Anatoly S. Karavaev,
  • Anatoly S. Karavaev,
  • Anatoly S. Karavaev,
  • Yurii M. Ishbulatov,
  • Yurii M. Ishbulatov,
  • Yurii M. Ishbulatov,
  • Mikhail D. Prokhorov,
  • Mikhail D. Prokhorov,
  • Vladimir I. Ponomarenko,
  • Anton R. Kiselev,
  • Anastasiia E. Runnova,
  • Anastasiia E. Runnova,
  • Alexey N. Hramkov,
  • Oxana V. Semyachkina-Glushkovskaya,
  • Jürgen Kurths,
  • Jürgen Kurths,
  • Jürgen Kurths,
  • Thomas Penzel,
  • Thomas Penzel

DOI
https://doi.org/10.3389/fphys.2020.612787
Journal volume & issue
Vol. 11

Abstract

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We propose a mathematical model of the human cardiovascular system. The model allows one to simulate the main heart rate, its variability under the influence of the autonomic nervous system, breathing process, and oscillations of blood pressure. For the first time, the model takes into account the activity of the cerebral cortex structures that modulate the autonomic control loops of blood circulation in the awake state and in various stages of sleep. The adequacy of the model is demonstrated by comparing its time series with experimental records of healthy subjects in the SIESTA database. The proposed model can become a useful tool for studying the characteristics of the cardiovascular system dynamics during sleep.

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