Nature Communications (Apr 2018)

Supramolecular latching system based on ultrastable synthetic binding pairs as versatile tools for protein imaging

  • Kyung Lock Kim,
  • Gihyun Sung,
  • Jaehwan Sim,
  • James Murray,
  • Meng Li,
  • Ara Lee,
  • Annadka Shrinidhi,
  • Kyeng Min Park,
  • Kimoon Kim

DOI
https://doi.org/10.1038/s41467-018-04161-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Although protein-ligand pairs are useful tools for bioimaging, they are susceptible to enzymatic degradation and interference from endogenous species. Here, the authors show that a synthetic and bioorthogonal cucurbit[7]uril-guest binding pair can be used to visualize proteins in cells, overcoming limitations of protein-based platforms.