TLR9 Polymorphisms Might Contribute to the Ethnicity Bias for EBV-Infected Nasopharyngeal Carcinoma
Nabanita Roy Chattopadhyay,
Koustav Chatterjee,
Nikhil Tiwari,
Sudipta Chakrabarti,
Sushil Kumar Sahu,
Sankar Deb Roy,
Arijit Ghosh,
R. Rajendra Reddy,
Piyanki Das,
Sudipa Mal,
Basab Bijay Karnar,
Ashok Kumar Das,
Sam Tsering,
Komri Riba,
Zoreng puii,
Eric Zomawia,
Y. Indibar Singh,
Amol Ratnakar Suryawanshi,
Abhishek Kumar,
Dipyaman Ganguly,
Chandan Goswami,
Tathagata Choudhuri
Affiliations
Nabanita Roy Chattopadhyay
Department of Biotechnology, Visva Bharati, Santiniketan, Bolpur 731235, India
Koustav Chatterjee
Department of Biotechnology, Visva Bharati, Santiniketan, Bolpur 731235, India
Nikhil Tiwari
School of Biological Science, National Institute of Science Education and Research, Padnpur, Odisha 752050, India
Sudipta Chakrabarti
Midnapore City College, Kuturia, Bhadutala, PaschimMedinipur 721129, India
Sushil Kumar Sahu
Depatrment of Pharmacology & Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Sankar Deb Roy
Department of Radiation Oncology, Eden Medical Center, Dimapur, Nagaland 797112, India
Arijit Ghosh
School of Biological Science, National Institute of Science Education and Research, Padnpur, Odisha 752050, India
R. Rajendra Reddy
Clinical Proteomics, Institute of Life Sciences, 751023 Bhubaneswar, India
Piyanki Das
Department of Biotechnology, Visva Bharati, Santiniketan, Bolpur 731235, India
Sudipa Mal
Department of Biotechnology, Visva Bharati, Santiniketan, Bolpur 731235, India
Basab Bijay Karnar
Department of Biotechnology, Visva Bharati, Santiniketan, Bolpur 731235, India
Ashok Kumar Das
Dr B. Borooah Cancer Institute, ENT Department, Guwahati, Assam 781016, India
Sam Tsering
Tertiary Cancer Center, TomoRiba Institute of Health and Medical Sciences, Naharlagun, Arunachal Pradesh 791110, India
Komri Riba
Tertiary Cancer Center, TomoRiba Institute of Health and Medical Sciences, Naharlagun, Arunachal Pradesh 791110, India
Zoreng puii
State Referral Hospital, Falkawn, Mizoram 796005, India
Eric Zomawia
State Referral Hospital, Falkawn, Mizoram 796005, India
Y. Indibar Singh
Department of Radiotherapy, Regional Institute of Medical Sciences, Imphal, Manipur 795004, India
Amol Ratnakar Suryawanshi
Clinical Proteomics, Institute of Life Sciences, 751023 Bhubaneswar, India
Abhishek Kumar
Institute of Bioinformatics, International Technology Park, 560100 Bangalore, India; Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India
Dipyaman Ganguly
Dendritic Cell Laboratory, Cancer Biology and Inflammatory Disorder, Indian Institute of Chemical Biology, 700032 Kolkata, India
Chandan Goswami
School of Biological Science, National Institute of Science Education and Research, Padnpur, Odisha 752050, India
Tathagata Choudhuri
Department of Biotechnology, Visva Bharati, Santiniketan, Bolpur 731235, India; Corresponding author
Summary: Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world, but is endemic in some ethnic groups. The association of NPC with the Epstein-Barr virus (EBV) is firmly established; however, the mechanism is still unclear. TLR9 is well known for its essential role in viral pathogen recognition and activation of innate immunity. Here, we report a set of TLR9 polymorphisms in the TIR-2 domain of the TLR9 protein collected from the EBV-infected NPC samples from northeast Indian populations sharing the aforesaid ethnicity. The occurrence of mutations is significantly high in these samples as we found a p value of <0.0001 at a significance level of 0.05. These might play an important role for the lack of function of TLR9 and thus for the higher occurrence of EBV-mediated NPC in such ethnic groups. : Biological Sciences; Human Genetics; Cancer Subject Areas: Biological Sciences, Human Genetics, Cancer
