An anionic ligand snap-locks a long-range interaction in a magnesium-folded riboswitch

Rajeev Yadav; Julia R. Widom; Adrien Chauvier; Nils G. Walter

doi:10.1038/s41467-021-27827-y

Nature Communications (Jan 2022)

An anionic ligand snap-locks a long-range interaction in a magnesium-folded riboswitch

Rajeev Yadav,
Julia R. Widom,
Adrien Chauvier,
Nils G. Walter

Affiliations

Rajeev Yadav: Single Molecule Analysis Group, Department of Chemistry and Center for RNA Biomedicine, University of Michigan
Julia R. Widom: Single Molecule Analysis Group, Department of Chemistry and Center for RNA Biomedicine, University of Michigan
Adrien Chauvier: Single Molecule Analysis Group, Department of Chemistry and Center for RNA Biomedicine, University of Michigan
Nils G. Walter: Single Molecule Analysis Group, Department of Chemistry and Center for RNA Biomedicine, University of Michigan

DOI: https://doi.org/10.1038/s41467-021-27827-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

Read online

A single molecule fluorescence study revealed three dynamically interconverting conformations of the fluoride riboswitch from Bacillus cereus, where an anionic ligand snap-locks a docked conformation through a long-range interaction necessary for downstream gene regulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal