Assessing the possibility of prevention, treatment and correction of the intestinal microflora dysbiotic disorders in experimental pseudotuberculosis

Abstract

The possibility was studied of preventing the development of pseudotuberculosis and correcting the dysbiotic disorders of the intestinal microflora in conventional white mice with prebiotic «Stimbifid» and exometabolites in supernatant fluids of native cultures of probiotic bifidobacteria and lactobacilli, which have prebiotic effect. Conventional white mice were infected orally with pseudotuberculosis microbe culture and the development of infection was evaluated. Prebiotic «Stimbifid» and supernatant fluid of lactobacilli native culture, administered to animals orally, as injected intramuscular gentamicin, completely stopped the infection development. In contrast to the antibiotic gentamicin prebiotic «Stimbifid» and supernatant fluid of lactobacilli native culture, administered orally, prevented the development of the intestinal dysbiosis in animals.

Keywords

• псевдотуберкулез
• белые мыши
• дисбактериоз
• пребиотик
• пробиотик
• экзометаболиты.