Nature Communications (May 2018)
TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression
- Silvia Ottaviani,
- Justin Stebbing,
- Adam E. Frampton,
- Sladjana Zagorac,
- Jonathan Krell,
- Alexander de Giorgio,
- Sara M. Trabulo,
- Van T. M. Nguyen,
- Luca Magnani,
- Hugang Feng,
- Elisa Giovannetti,
- Niccola Funel,
- Thomas M. Gress,
- Long R. Jiao,
- Ylenia Lombardo,
- Nicholas R. Lemoine,
- Christopher Heeschen,
- Leandro Castellano
Affiliations
- Silvia Ottaviani
- Department of Surgery and Cancer, Division of Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine (ICTEM)
- Justin Stebbing
- Department of Surgery and Cancer, Division of Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine (ICTEM)
- Adam E. Frampton
- Department of Surgery and Cancer, HPB Surgical Unit, Imperial College, Hammersmith Hospital Campus
- Sladjana Zagorac
- Department of Surgery and Cancer, Division of Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine (ICTEM)
- Jonathan Krell
- Department of Surgery and Cancer, Division of Cancer, Imperial College London, Institute of Reproductive and Developmental Biology (IRDB)
- Alexander de Giorgio
- Department of Surgery and Cancer, Division of Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine (ICTEM)
- Sara M. Trabulo
- Stem Cells & Cancer Group, Spanish National Cancer Research Centre (CNIO)
- Van T. M. Nguyen
- Department of Surgery and Cancer, Division of Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine (ICTEM)
- Luca Magnani
- Department of Surgery and Cancer, Division of Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine (ICTEM)
- Hugang Feng
- Epigenetics and Genome Stability Team, The Institute of Cancer Research
- Elisa Giovannetti
- Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam
- Niccola Funel
- Cancer Pharmacology Lab, AIRC Start-Up Unit, University of Pisa
- Thomas M. Gress
- Clinic for Gastroenterology, Endocrinology, Metabolism and Infectiology, Philipps-University Marburg
- Long R. Jiao
- Department of Surgery and Cancer, HPB Surgical Unit, Imperial College, Hammersmith Hospital Campus
- Ylenia Lombardo
- Department of Surgery and Cancer, Division of Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine (ICTEM)
- Nicholas R. Lemoine
- Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London
- Christopher Heeschen
- Stem Cells & Cancer Group, Spanish National Cancer Research Centre (CNIO)
- Leandro Castellano
- Department of Surgery and Cancer, Division of Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine (ICTEM)
- DOI
- https://doi.org/10.1038/s41467-018-03962-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 18
Abstract
In pancreatic ductal adenocarcinoma, TGF-β/Activin induce epithelial-to-mesenchymal transition (EMT) and stemness. Here, the authors show that TGF-β induces pro-tumourigenic miR-100 and miR-125b, but blocks anti-tumourigenic let-7a maturation via LIN28B, regulating pathways to promote stemness, EMT and tumourigenesis.
