Hypertension in Pregnancy (Jan 2021)

Contribution of long noncoding RNA HOTAIR variants to preeclampsia susceptibility in Iranian women

  • Sahra Esmkhani,
  • Hossein Sadeghi,
  • Majid Ghasemian,
  • Reihaneh Pirjani,
  • Mona Amin-Beidokhti,
  • Milad Gholami,
  • Fakhrolmolouk Yassaee,
  • Reza Mirfakhraie

DOI
https://doi.org/10.1080/10641955.2020.1855192
Journal volume & issue
Vol. 40, no. 1
pp. 29 – 35

Abstract

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Objective: To investigate the possible association of lncRNA HOTAIR rs920778 and rs874945 polymorphisms with preeclampsia risk in a sample from the Iranian population. Method: The study subjects included 250 preeclamptic women and 250 healthy women. The genotyping for rs920778 and rs874945 polymorphisms were performed using the TP-ARMS-PCR method. Results: HOTAIR rs920778 increased the risk of preeclampsia under the dominant and recessive inheritance patterns (OR = 4.84, 95% CI: 3.30–7.10, P < 0.0001; OR = 6.86, 95% CI: 3.51–13.42, P < 0.0001; respectively). Conclusion: This study confirmed the association of HOTAIR rs920778 polymorphism with preeclampsia in Iranian women. Further studies should be performed to confirm our findings.

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