miR-128-3p reduced acute lung injury induced by sepsis via targeting PEL12

Liu Shinan; Gao Shuai; Yang Zhaoyu; Zhang Peng

doi:10.1515/med-2021-0258

Open Medicine (Aug 2021)

miR-128-3p reduced acute lung injury induced by sepsis via targeting PEL12

Liu Shinan,
Gao Shuai,
Yang Zhaoyu,
Zhang Peng

Affiliations

Liu Shinan: Department of Thoracic Surgery, China Tianjin Medical University General Hospital, Tianjin, China
Gao Shuai: Department of Thoracic Surgery, China Tianjin Medical University General Hospital, Tianjin, China
Yang Zhaoyu: Department of Thoracic Surgery, China Tianjin Medical University General Hospital, Tianjin, China
Zhang Peng: Department of Thoracic Surgery, China Tianjin Medical University General Hospital, Tianjin, China

DOI: https://doi.org/10.1515/med-2021-0258
Journal volume & issue: Vol. 16, no. 1
pp. 1109 – 1120

Abstract

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Acute lung injury (ALI) caused by sepsis is clinically a syndrome, which is featured by damage to the alveolar epithelium and endothelium. In this study, we employed mice models of cecal ligation and puncture (CLP) and primary mice pulmonary microvascular endothelial cells (MPVECs) in vitro to investigate the effect of miR-128-3p in ALI caused by sepsis.

Published in Open Medicine

ISSN: 2391-5463 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine
Website: https://www.degruyter.com/journal/key/med/html

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