Nature Communications (Oct 2022)
A slit-diaphragm-associated protein network for dynamic control of renal filtration
- Maciej K. Kocylowski,
- Hande Aypek,
- Wolfgang Bildl,
- Martin Helmstädter,
- Philipp Trachte,
- Bernhard Dumoulin,
- Sina Wittösch,
- Lukas Kühne,
- Ute Aukschun,
- Carolin Teetzen,
- Oliver Kretz,
- Botond Gaal,
- Akos Kulik,
- Corinne Antignac,
- Geraldine Mollet,
- Anna Köttgen,
- Burulca Göcmen,
- Jochen Schwenk,
- Uwe Schulte,
- Tobias B. Huber,
- Bernd Fakler,
- Florian Grahammer
Affiliations
- Maciej K. Kocylowski
- Institute of Physiology, Faculty of Medicine, University of Freiburg
- Hande Aypek
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Wolfgang Bildl
- Institute of Physiology, Faculty of Medicine, University of Freiburg
- Martin Helmstädter
- Department of Medicine IV, Faculty of Medicine, University of Freiburg
- Philipp Trachte
- Department of Medicine IV, Faculty of Medicine, University of Freiburg
- Bernhard Dumoulin
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Sina Wittösch
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Lukas Kühne
- Department of Medicine IV, Faculty of Medicine, University of Freiburg
- Ute Aukschun
- Department of Medicine IV, Faculty of Medicine, University of Freiburg
- Carolin Teetzen
- Department of Medicine IV, Faculty of Medicine, University of Freiburg
- Oliver Kretz
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Botond Gaal
- Institute of Physiology, Faculty of Medicine, University of Freiburg
- Akos Kulik
- Institute of Physiology, Faculty of Medicine, University of Freiburg
- Corinne Antignac
- Laboratory of Hereditary Kidney Diseases, Imagine Institute, Paris Descartes University
- Geraldine Mollet
- Laboratory of Hereditary Kidney Diseases, Imagine Institute, Paris Descartes University
- Anna Köttgen
- Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg
- Burulca Göcmen
- Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg
- Jochen Schwenk
- Institute of Physiology, Faculty of Medicine, University of Freiburg
- Uwe Schulte
- Institute of Physiology, Faculty of Medicine, University of Freiburg
- Tobias B. Huber
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Bernd Fakler
- Institute of Physiology, Faculty of Medicine, University of Freiburg
- Florian Grahammer
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- DOI
- https://doi.org/10.1038/s41467-022-33748-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
The slit-diaphragm is a cellular junction that is crucial for blood filtration in the kidney. Kocylowski et al. show that the junction-spanning components are embedded in a protein network for dynamic control of filtration; network disturbance leads to severe filtration defects with proteinuria.
