Automated Bone Age Assessment with Image Registration Using Hand X-ray Images

Abstract

One of the methods for identifying growth disorder is by assessing the skeletal bone age. A child with a healthy growth rate will have approximately the same chronological and bone ages. It is important to detect any growth disorder as early as possible, so that mitigation treatment can be administered with less negative consequences. Recently, the most popular approach in assessing the discrepancy between bone and chronological ages is through the subjective protocol of Tanner–Whitehouse that assesses selected regions in the hand X-ray images. This approach relies heavily on the medical personnel experience, which produces a high intra-observer bias. Therefore, an automated bone age prediction system with image registration using hand X-ray images is proposed in order to complement the inexperienced doctors by providing the second opinion. The system relies on an optimized regression network using a novel residual separable convolution model. The regressor network requires an input image to be 299 × 299 pixels, which will be mapped to the predicted bone age through three modules of the Xception network. Moreover, the images will be pre-processed or registered first to a standardized and normalized pose using separable convolutional neural networks. Three steps image registration are performed by segmenting the hand regions, which will be rotated using angle calculated from four keypoints of interest, before positional alignment is applied to ensure the region of interest is located in the middle. The hand segmentation is based on DeepLab V3 plus architecture, while keypoints regressor for angle alignment is based on MobileNet V1 architecture, where both of them use separable convolution as the core operators. To avoid the pitfall of underfitting, synthetic data are generated while using various rotation angles, zooming factors, and shearing images in order to augment the training dataset. The experimental results show that the proposed method returns the lowest mean absolute error and mean squared error of 8.200 months and 121.902 months2, respectively. Hence, an error of less than one year is acceptable in predicting the bone age, which can serve as a good supplement tool for providing the second expert opinion. This work does not consider gender information, which is crucial in making a better prediction, as the male and female bone structures are naturally different.

Keywords

• skeletal bone age prediction
• regression network
• image registration
• X-ray image