Nature Communications (Dec 2020)

Genetic architecture of host proteins involved in SARS-CoV-2 infection

  • Maik Pietzner,
  • Eleanor Wheeler,
  • Julia Carrasco-Zanini,
  • Johannes Raffler,
  • Nicola D. Kerrison,
  • Erin Oerton,
  • Victoria P. W. Auyeung,
  • Jian’an Luan,
  • Chris Finan,
  • Juan P. Casas,
  • Rachel Ostroff,
  • Steve A. Williams,
  • Gabi Kastenmüller,
  • Markus Ralser,
  • Eric R. Gamazon,
  • Nicholas J. Wareham,
  • Aroon D. Hingorani,
  • Claudia Langenberg

DOI
https://doi.org/10.1038/s41467-020-19996-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Finding effective treatments for COVID-19 depends upon understanding genetic regulation of proteins involved in SARS-CoV-2 infection and host response. Here, the authors identify genetic variants linked to expression of such proteins, data which could lead to the discovery of therapeutic targets.