GABAergic dysfunction in pediatric neuro-developmental disorders

Abstract

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The GABAergic system is central to the development and functional maturation of the nervous system. Emerging evidence support the role of GABAergic dysfunction in neuro-developmental disorders. This review presents the molecules and mechanisms that underlie GABA system dysfunction in several neuro-developmental disorders presenting in childhood. The impact on synaptic plasticity, neuronal circuit function and behavior, followed by targeted treatment strategies are discussed.

Keywords

• Disease
• critical period
• synaptic plasticity
• circuits
• PV interneurons