Development of a new metronidazole delivery form and its clinical use in complex treatment of rectal cancer

Abstract

A review of russian and foreign literature concerning clinical use of metronidazole as a radiosensitizer in oncologic treatment. New delivery form of metronidazole has been developed using a polymeric composition. Dose- and time-dependent pharmacodynamics has been analyzed. Personal long-term results of complex treatment of localized and locally-advanced rectal cancer using different radiosensitizers has been presented. The data allows to consider complex treatment as a method of choice for these patients. Using polyradiomodification allowed to decrease lymphohematogenic metastasing rate, decrease locoregional recurrence rate and improve disease-free survival.

Keywords

• rectal cancer
• combined and complex treatment
• radiosensitizers
• polyradiomodification
• polymeric composition
• metronidazole
• hyperthermia