Nature Communications (Mar 2022)

Strain-level characterization of broad host range mobile genetic elements transferring antibiotic resistance from the human microbiome

  • Samuel C. Forster,
  • Junyan Liu,
  • Nitin Kumar,
  • Emily L. Gulliver,
  • Jodee A. Gould,
  • Alejandra Escobar-Zepeda,
  • Tapoka Mkandawire,
  • Lindsay J. Pike,
  • Yan Shao,
  • Mark D. Stares,
  • Hilary P. Browne,
  • B. Anne Neville,
  • Trevor D. Lawley

DOI
https://doi.org/10.1038/s41467-022-29096-9
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 9

Abstract

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Here, Forster et al. compare 1354 cultured commensal strains (540 species) to 45,403 pathogen strains (12 species), identifying 64,188 MGE-mediated antibiotic resistance gene transfer events between the two groups, and show that 15 broad host range MGEs are able to transfer between phyla.